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However, their impact on cAMP signaling induced by 10 M GLP-1(9-36) was different: from 85% in wildtype (WT) GLP-1R to 3% (Q234 3.37b A), 10% (V237 3.40b L) and 18% (V237 3.40b F), relative to the maximum response (100%) induced by GLP-1(7-36) ( Fig

Since CPP is a behavioral marker of a substances hedonic value, these results indicate that GLP-1RAs may attenuate the affective component of reinforcement, i.e., liking
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doi: 10.1002/cmdc.201200409 117 LennoxR.PorterD

That shift opens the door to practical problem-solving and helps preserve trust
