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Additionally, coffee influences the secretion of gastrointestinal peptides such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP), lowering glucose absorption in the small intestine [41,42], and activating central anorexigenic peptides (POMC/CART) as well as inhibiting orexigenic peptides (AgRP/NPY) [43,44]

This study further supports that this local destabilization is dependent on the nature of a non-polar branched or medium-long aliphatic amino acid side chain

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PMID: 63 GialouriCGPappaMEvangelatosGNikiphorouEFragoulisGE

Patients should not be asked to accept unproven therapies simply because effective, FDA-approved options are expensive or difficult to access. The Future of Compounded GLP-1s Is Uncertain Under U.S