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Zissin R, Osadchy A, Gutman V, et al

Similarly, genetic variants in the FTO gene (rs9939609) correlate with baseline appetite regulation capacity, meaning some individuals start with stronger hunger signals that semaglutide must overcome

Brian Wojeck, an obesity medicine specialist at the Yale School of Medicine, likened it to what happens after bariatric surgery, in which patients often experience temporary shedding due to stress and rapid metabolic change

it reflects your nervous system's ability to adjust to external chemical signals over time

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