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These data provide an explanation for CNS activation even though monoclonal antibodies have minimal brain penetrance, reaching concentrations of around 0.10.4% of the monoclonal antibody concentrations in the plasma 50,51

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doi: 10.4103/ijem.IJEM_185_19

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muciniphila cannot be completely classified as anti-or pro-inflammatory, but undoubtedly, plays an essential role in endotoxemia and diabetes-related chronic inflammation (Everard et al., 2013