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As for safety, there were no major side effects with either drug

This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about JARDIANCE as a treatment of adults with type 2 diabetes and established cardiovascular disease, and reflects Lillys current belief

Non-diabetic patients in these trials experienced benefits beyond weight reduction, including improved cardiovascular markers, better blood pressure control, and reduced inflammation

Often hitting multiple biological pathways is a more effective medication strategy than hitting just one pathway very aggressively

Drugs like semaglutide (Wegovy) and tirzepatide (Zepbound) have shown to improve efficacy compared to older weight-loss medications, with patients losing up to 20% of their body weight

Moreover, the weight loss achieved with GLP-1 RAs combined with lifestyle intervention approaches is comparable to that of surgical intervention, far surpassing the results adolescents can achieve through lifestyle changes alone ( This paper is a narrative review that references the SANRA guidelines for narrative reviews, but was not strictly written according to these guidelines