glp-1 agonist and dpp-4 inhibitor Receptor Agonists Have better Outcomes Than DPP4 Inhibitors in T2D patients & CKD How does sitagliptin work? DPP-4

When compared to single agonists, unimolecular dual incretin was more effective in correcting adiposity-induced insulin resistance in animal models of obesity and diabetes

doi: 10.1038/nrendo.2009.48

We compared GLP-1RAs with SGLT2 inhibitors and metformin and found that GLP-1RAs significantly reduced the incidence of major CVEs and mortality rate compared with metformin and second- or third-line glucose-lowering medications

Three years later, Byetta, the first GLP-1 agonist, was approved by the FDA

Our recommendation for a clear liquid diet for 24 h preprocedurally might appear overly restrictive

Poly-agonists : Drugs combining GLP-1 with other hormones (GIP, glucagon, amylin) to potentially increase weight loss