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This approach may maximize the impact of GLP-1 RAs by not only targeting metabolic and neurobiological dysfunctions but also reinforcing adherence, behavioral activation, and long-term recovery trajectories

[DOI] [PMC free article] [PubMed] [Google Scholar] 241.Lele R, Haller S, David K, Gutierrez G, Rahmani SK, Bailony MR

For each class of drugs, we analyzed the following parameters: average weight loss in kilograms, effects on body mass index (BMI), and changes in body composition.Our findings suggest that anti-diabetic drugs can be categorized into three groups based on their efficacy in promoting weight loss

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32-37 This large trial is likely to provide more clarity on whether dual agonism through tirzepatide lead to even greater benefits in patients with T2D and established CV disease than a GLP-1RA based approach

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