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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

It is a predictable physiological reality of significant weight loss: as the body's overall mass decreases, it requires less structural support and energy

We hypothesized that muscarine might act similar to acetylcholine

Semaglutide eligibility goes beyond BMI alone

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For a country facing over 100 million people with type-2 diabetes and a rapidly rising obesity burden, this is more than a commercial milestoneit is a public health opportunity