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Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity

When prescribed in the usual oral dosage range of 250 to ~2550 mg/day for the treatment of T2DM and in the absence of reduced renal function, it is unlikely that peak plasma levels of metformin would exceed 15-20 M, with trough levels of between 1-5 M, and a plasma half-life of approximately 3 to 5 hours

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Interleukin-6 predicts inflammation-induced increase of glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism