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Weincluding health-care professionalswould blame people challenged by their inability to lose weight, he says

10.1093/jnci/djq526 [EL 2

It is available on prescription in the UK at a cost of around 300 a month

In the Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron produced mean body weight reductions of 7.5% (6 mg), 8.4% (12 mg), and 11.2% (36 mg) at 72 weeks, compared with 2.1% for placebo

Both ANP and GLP-1R agonists showed bronchodilatory effects, with stronger responses in COPD mice

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