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Not all formulations contain enough B12 to fully offset absorption losses, especially at higher semaglutide doses

The most commonly reported AE with tirzepatide were gastrointestinal, including nausea, diarrhoea and vomiting

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GLP-1 medications do not replace or reduce the need for disease-modifying antirheumatic drugs (DMARDs)

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In some of these clinical studies, liraglutide treatment had been used for up to 52 weeks at doses ranging up to 3 mg daily (only in nondiabetic obese populations) or up to 1.8 mg daily (patients with type 2 diabetes) with no systematic change in calcitonin concentrations indicating any measurable response to GLP-1 receptor stimulation (34)
