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The use of GLP-1 analogs is growing rapidly in obese and overweight patients who need to control body weight.

Its pathogenesis is unknown

In this study, human umbilical vein endothelial cells (HUVECs), exposed to palmitic acid (PA) to induce endothelial dysfunction, were incubated with metformin, liraglutide or their combination

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It highlights emerging evidence, safety considerations, and equity challenges that position GLP-1 RAs as a promising public health strategy for this high-risk population.