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In the SURPASS-4 study, which enrolled patients with established cardiovascular disease, weight-loss independent effects explained 33% to 57% of difference in SBP change between tirzepatide and insulin glargine groups

GLP-1 weight loss drugs like Ozempic are reshaping obesity care, eating habits, and boosting demand for fast-absorbing protein.

LH and FSH signaling related to testosterone production

The metabolic rate of GLP-1R KO mice was significantly slower than that of WT mice (p=0.0345, WT mice 0.023350.057mM/min, GLP-1R KO mice 0.019980.07mM/min)

The fermentation of fiber in the gut leads to the production of short-chain fatty acids, which can stimulate GLP-1 secretion

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