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Indeed, administering GLP-1R agonists into the fourth ventricle in mice decreases food intake and body weight [21, 22], and GLP-1R knockdown in NTS neurons increases food intake [23, 23]

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10.1016/j.biopha.2020.110523 141 LiaoH.-Y.WangC.-Y.LeeC.-H.KaoH.-L.WuW.-K.KuoC.-H

In the United States, although men have higher age-adjusted mortality rates for 8 of the 10 leading causes of death, AD is a notable exception: women experience higher prevalence and AD-specific mortality, making it the only major cause of death more common in women ( Today, nearly two-thirds of patients receiving medical care for AD are women