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A study using Swedish and Danish national databases compared cancer incidence in over 20,000 GLP-1 users versus other diabetes medications and found no elevated risk for colon or rectal cancers during follow-up periods extending beyond three years

The Glucagon Receptor Is Involved in Mediating the Body Weight-Lowering Effects of Oxyntomodulin

In the UK, SCoMIS has been announced in 2025, a landmark government-funded and IQVIA-run study will enrol thousands of patients, including those from Scotlands most deprived areas, to assess the impact of obesity treatments in real-world settings

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Summary: GLP-1 medications slow gut motility and gastric emptying, leading to harder stools and constipation, which can be managed through increased dietary fibre, adequate hydration, regular physical activity, and appropriate laxative use when necessary