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Am J Respir Crit Care

Your metabolism adapts: Studies on metabolic flexibility show that over time, your body becomes more efficient at switching between burning sugar and burning fat for energy

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However, there was a significant growth inhibitory effect of semaglutide alone, which could be clinically significant to decrease the growth of cells refractory to standard-of-care AR-targeted therapy (Figure 4A)

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These differing mechanisms of action explain why combining these medications theoretically might produce additive weight loss effects, but also why such combination therapy raises substantial safety concerns that have not been adequately studied in clinical trials