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In a phase 2a trial specifically examining metabolic dysfunction-associated steatotic liver disease, the 8 mg retatrutide group showed 81.7% mean relative reduction in liver fat, and the 12 mg group showed 86% reduction

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The participant group was predominantly white (92%) and female (79%)

Four patients discontinued therapy due to gastrointestinal side effects, with three of them in the injectable group and one in the oral group.[1] This lower adverse event rate in the injectable group is noteworthy for patients concerned about tolerability