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Managing Side Effects When Restarting Proactive management of side effects makes restarting more comfortable and increases the likelihood you will stick with treatment long enough to see benefits

Use of these agents has been associated with a modest increase in lipase and amylase levels (by 15 and 37%, respectively, in one study 47 ), but this is rarely of any clinical significance

The idea is that tiny doses can give benefits with fewer side effects

These effects result in very significant weight loss (15-20% of initial body weight), i.e., of the same order of magnitude as that obtained by bariatric surgery

Semaglutide's Direct Mechanism for Weight Loss Semaglutide is a GLP-1 receptor agonist that mimics glucagon-like peptide-1, a hormone your intestines naturally release after eating

Most (70% to 80%) lost 5% or more of their body weight