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Oral sermorelin (swallowed) has near-zero bioavailability
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Options at plateau include maintaining the current dose to prevent regain (the STEP 4 trial showed rapid weight regain after discontinuation), adding structured exercise to increase energy expenditure, reviewing dietary quality rather than just quantity, and in some cases, considering a temporary dose increase if prescribed by a provider
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Prioritising safe medication management means recognising that these therapies are powerful clinical tools
