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Hypertrophic adipocytes undergo phenotypic changes and begin to secrete inflammatory adipokines (bioactive molecules released from an adipocyte) and cytokines (immune signaling molecules involved in inflammation, immunity, and cell communication)
These actions combine to reduce overall caloric intake, facilitating weight loss when used alongside dietary modification and increased physical activity

doi: 10.1126/scitranslmed.3006438 93 WadhwaE

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