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Key Takeaways Tirzepatide and semaglutide are both once-weekly injectable medications for diabetes and weight management, but tirzepatide targets both GLP-1 and GIP receptors while semaglutide targets only GLP-1

This design is particularly helpful for patients with limited dexterity, visual impairments, or those new to injectable treatments

Some observers have opined that the European agency is stricter than the US Food and Drug Administration, which has not yet addressed this issue

Retatrutide and orforglipron are furthest along in testing, while survodutide may take longer

If youre looking for more effective options, prescription medications like Wegovy and Mounjaro are available through regulated providers

Coverage for obesity indications (Wegovy, Saxenda, Zepbound) remains more limited