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David Ahn, an endocrinologist at Hoag, a health care system in Southern California

By synthesizing transcriptomic, pharmacokinetic, signaling, and pharmacovigilance findings into a coherent mechanistic framework, this narrative review addresses an unrecognized area of GLP-1 biology and provides the first integrated hypothesis on how prolonged GLP-1R activation could disrupt salivary gland function

Previous studies have demonstrated that the cAMP/p-AMPK/p-ACC and insulin-sensitizing pathways are pivotal to GLP-1s beneficial effects on hepatic lipid metabolism

In conclusion, both Wegovy and Mounjaro offer promising options for individuals struggling with obesity or overweight conditions

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The purpose of this paper is to critically examine the inconsistencies of currently published data, examine the appropriateness of the current guidelines and to further educate anesthesiologists on the importance of informed perioperative assessment and management of these patients