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Glucagon receptor-mediated hepatic fat mobilisation is the mechanistic differentiator from GLP-1/GIP compounds in this indication

SGLT2 inhibitors may be similarly preferred for individuals with ASCVD, HF, and CKD and appear to be safe and effective in PTDM (304309)

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Mean values were then calculated for all contractions within the control period, as well as following treatment with semaglutide, and these are represented as a single datapoint in Figure 3I

We additionally assessed inflammatory involvement in peri-pancreatic adipose tissue, a visceral fat depot enriched in leukocytes and implicated as a source of mediators affecting -cell dysfunction 23,24

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