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Hyperglycemia, impaired glucose tolerance, and glycosuria can occur during hydrochlorothiazide therapy, and blood and/or urine glucose levels should be assessed more carefully in patients with diabetes mellitus who are receiving hydrochlorothiazide

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Blood samples for assessment of glucose metabolism parameters (glucose, insulin, C-peptide, glucagon, and pro-insulin) were collected during fasting state: at baseline (before first dosing), 1 week after the fourth dose of 0.5 mg, and 1 week following the final dose

In vitro, semaglutide corrected DHT-induced GPX4 hypermethylation and ferroptosis in granulosa cells

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