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Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways

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The positive impact of GLP-1RA therapy on lipids is an important contributor to these outcomes.

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In the U.S., about 75% of adults are overweight or obese. Children arent spared