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However, to date, there is only one randomized clinical trial of GLP-1 RAs (the ELIXA study) evaluating major cardiovascular events as their primary outcomes, and in this study, a neutral cardiovascular effect of lixisenatide was observed in high-risk diabetic subjects

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In a separate trial, adolescents lost about 16% of their starting body weight on average

Dan Azagury, MD, section chief of Minimally Invasive and Bariatric Surgery and medical director for the Bariatric and Metabolic Interdisciplinary clinic at Stanford Medicine, told Healthline that while the data confirm the GI side effects, he is concerned about the narrative around gastroparesis

Semaglutide, on the other hand, is more focused, targeting only the GLP-1 receptor

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