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Weight loss during pregnancy is not recommended, as it can deprive the fetus of essential nutrients

Upon activation of the GLP-1 receptor, cAMP levels increase, which activates the cAMP response element-binding protein (CREB) (Kida and Serita, 2014)

However, its direct therapeutic application is limited by its rapid inactivation via the enzyme dipeptidyl peptidase 4 (DPP-4), which cleaves GLP-1 (736) at position 8 to generate the inactive metabolite GLP-1 (936), resulting in a plasma half-life of only 1 to 2 min

Myth 3: Protein and water are the only things I need to worry about

The 2024 Journal of Cosmetic Dermatology commentary by Andriotis and Dayan (PMC11845967) explicitly recommended this combination approach, noting that effective management of facial volume loss, skin laxity, and body contour challenges following GLP-1 weight loss requires a combination of injectable treatments, energy-based devices, and in some cases surgical interventions

Erica, this is the conversation nobody wants to have