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Finally, tirzepatide may influence key transcription factors involved in lipid metabolism, such as SREBP-1c and PPAR-/, and by improving systemic insulin sensitivity and promoting weight loss, it could push hepatocytes toward a less lipogenic gene expression profile [34]

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Semaglutide has shown to improve glycemic control, with many patients seeing improvements in blood sugar levels within 8 to 12 weeks of starting treatment

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Glycemic control, weight management, cardiovascular safety, and cost-effectiveness of semaglutide for patients with type 2 diabetes mellitus: a rapid review and meta-analysis of real-world studies
