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Between 30 million and 50 million US adults could be taking a GLP-1 by 2034. In December 2024, 1.9 million prescriptions of GLP-1s to treat obesity (as opposed to diabetes, for example) were filled, nearly quadruple the number YoY, per IQVIA

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A new study has revealed that most Australian women of reproductive age prescribed GLP-1 receptor agonists are not using effective contraception, despite known risks during pregnancy.

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(For a detailed history, I recommend Megan Molteni and Elaine Chens piece for STAT.) The benefits of these drugs are undeniable, but when it comes to evaluating their risks, we run into challenges that researchers are familiar with but that the public at large may not be aware of

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