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A new generation of dual and triple receptor modulators targeting nutrient-stimulated hormone pathways are producing cardiometabolic effects that exceed any previous pharmacotherapy, with weight loss efficacy approaching that of bariatric surgery

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As the use of GLP-1 receptor agonists continues to expand for the treatment of type 2 diabetes and obesity, questions have emerged about their potential gastrointestinal side effectsparticularly gastroesophageal reflux disease (GERD)

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