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The STEP (Semaglutide Treatment Effect in People with obesity) trials, which included over 4,500 participants, showed that semaglutide 2.4 mg weekly resulted in mean weight loss of 12.4% to 15.3% of initial body weight over 68 weeks, compared to 2.4% to 3.2% with placebo

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ng ch , nhm thuc GLP-1 (vn dng trong iu tr i tho ng) ang c ghi nhn c li cho vic h tr hi phc sc khe tim mch

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Similar results were seen in diabetic rats fed a diet rich in monounsaturated fatty acids from olive oil, where GLP-1 levels increased, weight gain decreased, and insulin sensitivity improved

Both trials demonstrated dose-dependent efficacy that appeared competitive with injectable GLP-1 agonists (see our drug comparison hub), a finding that electrified the pharmaceutical industry and investor community