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Description

Rodent studies revealed that administration of GLP-1R agonists to the central or peripheral nervous system can activate a subset of GLP1Rexpressing neurons and produce weight loss [10, 11]

Market Opportunity : Major opportunities include oral GLP-1 innovations, combination therapies integrating GIP/GLP-1 pathways, improved affordability for emerging markets, expanding indications beyond diabetes and obesity, and partnerships to enhance manufacturing capacity, distribution, and long-term patient adherence

The effect of GLP-1 receptor agonists on circulating inflammatory markers in type 2 diabetes patients: A systematic review and meta-analysis

Other companies have active efforts in this space such as efinopegdutide (MK-6024) (51), pemvidutide (Altimmune, ALT-801) and mazdutide (LY3305677, IBI362, 52)

Whilst once-weekly preparations such as semaglutide and dulaglutide can be administered at any time of day, other formulations have more specific timing requirements