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Risk of hypoglycemia, dehydration, and nutrient depletion is higher in these populations

GLP-1R agonists (GLP-1 and exendin-4) opposed this efflux of K + as demonstrated by experiments conducted in rat -cells which showed an inhibitory effect of exendin-4 on voltage-dependent outward K + currents [76]

Persistent nausea lasting beyond the first few weeks of therapy, vomiting more than twice daily, or diarrhea occurring more than three times daily significantly increases electrolyte loss risk

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However, significant questions remain about these drugs