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The strengths of this study are its population-based design, with PBS/RPBS prescription supply data highly representative of medication use by the Australian population

The average weight loss for study subjects who did not have diabetes and used the largest dose was approximately 18%

At least two states changed their coverage criteria

Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes

While not yet FDA approved (currently in Phase 3 trials), research-grade retatrutide is widely available through peptide suppliers, though quality varies widely and the safest route is lab-tested retatrutide with per-batch certificates

Our focus is on steady, sustainable progress that leads to long-term health benefits, rather than an unhealthy 'quick fix'