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Why Nausea Happens GLP-1 drugs work by slowing digestion, increasing satiety, and regulating blood sugar

As mentioned earlier, estradiol impacts vagal nerve fiber excitability and density

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Additionally, tirzepatide exhibited a substantial reduction in major adverse cardiovascular events and cardiovascular death compared to placebo in a pooled analyses of the SURMOUNT-1 and SURPASS trials [34]

While norepinephrine seemingly inhibits GLP-1 secretion via its action on -adrenergic receptors, its secretion is stimulated by isoproterenol, and this effect can be blocked by co-infusion of the -adrenergic receptor antagonist propanolol [337]