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Lumps Under The Skin Small lumps or firm areas under the skin are usually a sign of lipohypertrophy, caused by injecting into the same spot too frequently

Tirzepatide and semaglutide remain the most widely used medical options for clinically significant weight loss under professional supervision

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While those taking semaglutide (Wegovy) and tirzepatide (Mounjaro) lost double the amount of weight compared with people using older jabs 16kg on average patients put on 9.6kg within a year, meaning they could expect to regain all 16kg again in just over 20 months

The body often adapts over days to weeks as receptors settle into new signaling patterns