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Considering the central role of glucose catabolism for stimulus-secretion coupling in -cells, our findings suggest that chronic GLP-1 actions on insulin secretion include elevated -cell glucose metabolism

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Objective To determine whether the use of glucagon-like peptide-1 (GLP-1) receptor agonists is associated with an increased risk of suicidal ideation, self-harm, and suicide among patients with type 2 diabetes compared with the use of dipeptidyl peptidase-4 (DPP-4) inhibitors or sodium-glucose cotransporter-2 (SGLT-2) inhibitors