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Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7), a Phase 3b trial of semaglutide, demonstrated that semaglutide was superior to dulaglutide in improving glycemic control and weight loss 10

It may also reduce mobility and increase stress

The evidence still strongly suggests that weight loss is a valuable investment in fighting at least some major kinds of future pain for many people, and we have strong reasons to believe its a metabolic effect rather than a mechanical one, and probably isnt limited to arthritis

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8 Mori and Pacific peoples with type 2 diabetes have worse health outcomes compared to Europeans

The findings, which were presented over the weekend at ENDO 2026, the Endocrine Society's annual meeting, were based on an analysis of health records from more than 42,000 adults who were already taking at least two types of blood pressure medications when they began treatment with GLP-1 drugs such as semaglutide, tirzepatide or liraglutide