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Not drinking enough water and fluids can also cause tiredness

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Serotonin reuptake inhibitors, like sibutramine and fluoxetine, as well as monoamine oxidase inhibitors like clorgyline and pargyline, have demonstrated effectiveness in reducing food intake [105,106,107]

Their findings increasingly support this idea, suggesting that effective therapy might require engaging both systems differently

Tirzepatide became the first dual GLP/GLP-1 receptor agonist to gain FDA approval for treating T2DM in 2022 and obesity in 2023 [ Table 2 ]