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Earlier Phase 2 data had already started the conversation as it showed a lot of promise

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Risk-benefit implications With increasing prevalence of GLP-1 agonists in our perioperative population and emerging reports of retained gastric content despite recommended fasting guidelines, a review on the perioperative handling of GLP-1 agonists and assessment of these patients are warranted to balance their cardiometabolic benefits and unquantified risk of catastrophic pulmonary aspiration

These results are really incredible, said Caroline Apovian, MD, a Professor of Medicine at Harvard Medical School and the co-director of the Center for Weight Management and Wellness at Brigham and Womens Hospital

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doi: 10.1038/ni.3133 19 KorneliusE.HuangJ