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By pre-treating rats with the non-specific cholinergic receptor antagonist atropine as well as the specific M3 cholinergic receptor antagonist 4-DAMP and performing vagotomy, the researchers found that atropine and 4-DAMP significantly reduced metformin-induced GLP-1 secretion, whereas vagotomy had no effect on metformin-induced GLP-1 secretion
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Front Endocrinol (Lausanne) 2021;12:698619.ArticlePubMedPMC 85
Zhang, Q., Xiao, X., Li, M., Li, W., Yu, M., Zhang, H., et al
