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Consistent findings have shown that GLP-1R agonism promotes weight loss and improves glucose homeostasis in rodents, monkeys, and humans (Verdich et al., 2001

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Recurrent yeast infectionsdefined as four or more confirmed episodes within 12 monthsnecessitate comprehensive evaluation

Lastly, future directions include the development of clinically feasible GLP-1R antagonists, the identification of predictive biomarkers to guide patient selection and the integration of this approach into rational combinatorial immunotherapy regimens

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