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When the heart is ruled out and no clear cause is found, the pain is labeled non-specific

10.1056/NEJMe2114918 [EL 4

(3) an underlying inflammatory or catabolic condition may be contributing review for thyroid dysfunction, chronic inflammation markers, or medication interactions

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Some of these are based on motility, maturity as shown by hyaluronic acid levels, detection of apoptosis markers like phosphatidylserine at high levels, normal morphology, and sex