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Clinical and pre-clinical osteoarthritis research suggests that semaglutide reduces pain scores and cartilage loss over 2 years, compared to placebo [1], and pre-clinical research showed that a similar drug (liraglutide) reduced fibrosis of the joint synovium and reduced pain severity, despite no difference in weight-loss compared to the control groups [1]

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Reduce caffeine and alcohol intake, as they can contribute to dehydration

While weight loss typically improves these conditions over time, symptoms may fluctuate during the weight loss period