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Description
In the SURPASS J-Mono trial, tirzepatide was compared to a weekly dose of 0.75 mg dulaglutide, although doses of up to 4.5 mg once weekly have been approved (and have demonstrated enhanced efficacy)
Figure 1 4.1 Type 2 diabetes Obesity and type 2 diabetes (T2D) are strongly linked
If patients experience intolerable side effects during dose escalation, healthcare providers may consider delaying the increase for an additional four weeks or maintaining the current dose if therapeutic goals are being met
Options include booking accommodations with refrigerators (most hotels provide mini-fridges on request), using the 21-day room temperature allowance strategically, or carrying a portable injection system with proper cooling
Armistead B, Johnson E, VanderKamp R, et al
Each appears in roughly 1% or less of trial participants but needs prompt evaluation if symptoms develop
