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GLP-1RAs have been shown to greatly reduce the body weight of obese people with type 2 diabetes.814 The US Food and Drug Administration has approved several different formulations or doses of GLP-1RAs for the treatment of type 2 diabetes: exenatide, liraglutide, dulaglutide, albiglutide, lixisenatide, semaglutide, and tirzepatide.15 Given the wide variety of GLP-1RA drugs, the differences in pharmacokinetics, efficacy, adverse reaction rates, and dosing requirements of each GLP-1RA need to be evaluated independently.16 Additionally, clinicians need to understand the advantages and disadvantages of each GLP-1RA drug to reach the appropriate clinical decisions

Slower digestion, reduced fluid intake, and changes in gut movement all work together to increase the risk of constipation

2 There are six FDA-approved GLP-1 RAs on the market, including several that are widely recognized in the popular media: exenatide (Byetta, Bydureon)

Some of that data is coming soon, says Dr

AMPK = adenosine monophosphate-activated protein kinase