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Introduction Retatrutide is a nextgeneration metabolic drug designed to tackle obesity and associated conditions by simultaneously activating three key hormone receptors involved in metabolic regulation: glucagonlike peptide1 (GLP1), glucosedependent insulinotropic polypeptide (GIP), and glucagon receptors

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Na V 1.8 was detected in a subset of postganglionic neurons in thoracic sympathetic ganglia in humans and mice, where p.R14L produced a gain-of-function profile that enhanced cholinergic responsiveness

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