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However, your body can produce pro-inflammatory cytokines, which are part of the normal immune response but can exacerbate conditions and contribute to migraine development
SURMOUNT-1 (Jastreboff 2022, NEJM) reported up to 20.9 percent average weight loss with tirzepatide versus 14.9 percent with semaglutide in STEP 1 (Wilding 2021, NEJM)

Therefore, postmarketing surveillance and real-world evidence play a crucial role in continuously monitoring the safety and effectiveness of medications once they are in widespread use [Reference Zhou, Peng, Lin, Jiang, Peng and Gu29Reference Fan, Hu, Yang and Zhao31]
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[DOI] [PubMed] [Google Scholar] 14.Rowe T.A., Juthani-Mehta M

Arnott C, Neuen BL, Heerspink HJ, Figtree GA, Kosiborod M, Lam CS, et al
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However, whether these biochemical changes translate into meaningful clinical benefits remains uncertain
