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In addition to this endocrine action, the local inhibitory effect of DPP-4 inhibitors on GLP-1 degradation in the intestinal mucosa may contribute to favorable metabolic regulation by stimulating the autonomic afferent nervous system (10, 19)

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DURATION diabetes therapy utilization: researching changes in A1C, weight and other factors through intervention with exenatide QW (extended-release exenatide, 2 mg, once weekly), EQW exenatide QW, HDL-C high density lipoprotein cholesterol, GLP-1 RA glucagon-like peptide-1 receptor agonist, LDL-C low density lipoprotein cholesterol, RCTs randomised controlled trials, T2DM type 2 diabetes mellitus, TZD thiazolidinediones Table 15

doi: 10.1016/S0140-6736(24)01763-X

doi: 10.1038/s41366-020-0535-5 79

Discussion GLP-1RA fills increased rapidly between 2018 and 2023