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doi: 10.1016/0024-3205(85)90203-6

The pathogenetic reasons underlying this interplay are not yet fully understood, but various hypotheses have been formulated

Mounjaro has a greater potential effect for weight loss due to this dual mechanism of action

Early clinical studies suggest that patients taking Tirzepatide experience significant weight loss, even when compared to other medications in its class

For mechanistic comparison with single and dual agonists, see our GLP-1 metabolic research guide

While isolated case reports may exist in post-marketing surveillance, regulatory authorities have not issued safety alerts linking GLP-1 receptor agonists to colitis development